The structure of human parvovirus B19
نویسندگان
چکیده
منابع مشابه
The structure of human parvovirus B19.
Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure of recombinant B19-like particles has been determined to approximately 3.5-A resolution by x-ray crystallography and, to our knowledge, represents the first near-atomic structure of an Erythrovirus. The polypeptide fold of the major capsid protein VP2 is a "jelly roll" with a beta-barrel motif similar to tha...
متن کاملmiRNA and tropism of human parvovirus B19
Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpr...
متن کاملParvovirus B19.
N Engl J Med 2004;350:586-97. Copyright © 2004 Massachusetts Medical Society. vonne cossart, an australian virologist working in london in the mid-1970s, noted an anomalous reaction of a normal blood donor’s serum (occupying position 19 in plate B) in an assay for hepatitis B. When Cossart excised the line of antigen–antibody precipitation, she saw the particles shown in Figure 1A, and in this ...
متن کاملHuman parvovirus B19 and pediatric rheumatologic disease
Purpose Human Parvovirus B19 causes a self-limited febrile illness with a characteristic exanthem and occasional acute arthritis. B19 infection has also been associated with multiple rheumatic diseases. Reports indicate that in patients with positive B19 PCR up to ~1/3 have negative IgM and positive IgG to B19. However little is known about how these findings might relate to rheumatologic sympt...
متن کاملRheumatoid arthritis after human parvovirus B19 infection.
Polyarthropathy associated with human parvovirus B19 (B19) is usually transient, but often resembles rheumatoid arthritis (RA). However, B19 DNA screened by polymerase chain reaction (PCR) may be positive not only in autoimmune diseases, but also in non-arthropathy. To study whether or not RA occurs after acute B19 infection, we conducted a prospective study of patients with acute onset polyart...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0402992101